Selected Publications (Complete List Here)

Research Articles

PDF  Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, Diamond MS (2016) A Mouse model of Zika virus pathogenesis. Cell Host and Microbe. 19(5):720-30.

PDF  Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M Jr, Klein RS, Diamond MS (2015) Interferon lambda restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Science Translational Medicine. 7(284):284ra59.

PDF  Widman DG, Young E, Yount BL, Plante KS, Gallichotte EN, Carbaugh DL, Peck KM, Plante J, Swanstrom J, Heise MT, Lazear HM, Baric RS (2017) A Reverse Genetics Platform That Spans the Zika Virus Family Tree. MBio. 8(2)pii: e02014-16.

PDF Collins MH, McGowan E, Jadi R, Young E, Lopez CA, Baric RS, Lazear HM, de Silva AM. (2017) Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection. Emerging Infectious Diseases. 23(5):773-781.

PDF  Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray LB, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, Gale M Jr, Fruh K, Diamond MS (2013) IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathogens. 9(1): e1003118.

PDF  Lazear HM, Pinto AK, Ramos HJ, Vick SC, Shrestha B, Suthar MS, Gale M Jr, Diamond MS (2013) Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system. Journal of Virology. 87(21):11401-15.

PDF  Lazear HM, Pinto AK, Vogt MR, Gale M Jr, Diamond MS (2011) Beta interferon controls West Nile virus infection and pathogenesis in mice. Journal of Virology.  85:7186-7194.

 

Reviews & Commentaries

PDF Casazza RL, Lazear HM (2018) Antiviral immunity backfires: Pathogenic effects of type I interferon signaling in fetal development. Science Immunology. 5;3(19). pii: eaar3446. PMID 29305463

PDF  Coyne CB, HM Lazear (2016) Zika virus – reigniting the TORCH. Nature Reviews Microbiology. 14(11):707-715.

PDF  Lazear HM, Diamond MS (2016) Zika Virus: New Clinical Syndromes and its Emergence in the Western Hemisphere. Journal of Virology.  90(10):4864-75.

PDF  Lazear HM (2017) What to Expect When You're Expecting Zika. Cell Host and Microbe. 21(3):305-308.

PDF  Lazear HM, Stringer EM, de Silva AM (2016) The Emerging Zika Virus Epidemic in the Americas: Research Priorities. JAMA. 315(18):1945-6.

PDF  Lazear HM, Nice TJ, Diamond MS (2015) Interferon-λ: Immune Functions at Barrier Surfaces and Beyond. Immunity. 43(1):15-28.

PDF  Lazear HM, Diamond MS (2015) New insights into innate immune restriction of West Nile virus infection. Current Opinion in Virology. 11:1-6.